Christina Chan Recent Publications
Reviewed Journal Publications
Kidambi, S., Lee, I, and Chan, C., “Directed deposition of cells and macromolecules using salt tunable m-dPEG acid patterns on polyelectrolyte multilayers”, (2007) Langmiur, (in press).
Srivastava, S., Li, Z., Yang, X., Yedwabnick, M., Shaw, S., and Chan, C., “Identification of genes that regulate multiple cellular processes/ responses in the context of lipotoxicity in hepatoma cells”, (2007) BMC Genomics, 8:364. Link to publication
Patil, S., Melrose, J., and Chan, C., “Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons”, (2007) European Journal of Neuroscience. 26(8):2131-41. Link to publication
Kidambi, S., Lee, I, and Chan, C., “Patterned Co-culture of Neurons and Astrocytes on Polyelectrolyte Multilayer Films for Studying Astrocyte Mediated Oxidative Stress in Neurons”, (2007) Advanced Functional Materials (in press).
Srivastava, S. and Chan, C., “Application of Metabolic Flux Analysis to Identify the Mechanisms of Free Fatty Acid Toxicity to Human Hepatoma Cell Line, HepG2”, (2007) Biotechnology and Bioengineering, 2007 Jul 5; [Epub ahead of print] . Link to publication
Jin, R. , Si, L., and Chan, C., “A Bayesian Framework for Knowledge Driven Regression Model In Micro-array Data Analysis”, International Journal of Data Mining and Bioinformatics (IJDMB) (in press).
Li, Z. , Srivastava, S., Yang, X., Mittal, S., Sheng, L., and Chan, C., “A Three Stage Integrative Pathway Search (TIPS ©) framework to identify toxicity relevant genes and pathways”, (2007) BMC Bioinformatics, June 14; 8(101):1-17. Link to publication
Li, Z., Srivastava, S., Mittal, S., Norton, P., Resau, J., Haab, B, and Chan, C., “A Hierarchical Approach Employing Metabolic and Gene Expression Profiles to Identify Pathways that Confer Fatty Acid and TNF-α Cytotoxicity in HepG2 Cells”, (2007) BMC Systems Biology, 1(21), 1-15. Link to publication
Kidambi, S., Udpa, N., Schroeder, S.A, Lee, I, and Chan, C., “Cell Adhesion on Polyelectrolyte Multilayer Coated Poly(dimethylsiloxane) Surfaces with Varying Topographies”, Tissue Engineering, (2007) 13(8):2105-17. Link to publication
Kidambi, S ., Sheng, L., Toner, M., Yarmush, M., Lee, I, and Chan, C., “Patterned Co-culture of Primary Hepatocytes and Fibroblasts using Polyelectrolyte Multilayer Templates”, Macromolecular Bioscience, (2007) (3): 344 - 353. Link to publication
Srivastava, S. , and Chan, C., “Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to MPT”, (2007) Free Radical Research, 41(1):38-49. Link to publication
Patil, S., Sheng, L., Masserang, A., and Chan, C., “Palmitic acid-induced BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons”, (2006) Neuroscience Lett., 406: 55–59. Link to publication
Li, Z. , Shaw, S. M., Yedwabnick, M. J., and Chan, C., “Using a state-space model with hidden variables to infer transcription factor activities”, (2006) Bioinformatics, 22(6): 747–754. Link to publication
Patil, S. and Chan, C., “Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons”, (2005) Neuroscience Lett., 384(3):288-293. Link to publication
Kidambi, S. , Lee, I., and Chan, C., “Controlling Primary Hepatocyte Adhesion and Spreading on Protein Free Polyelectrolyte Multilayer Films”, (2004) JACS Communications, 126(50):16286-7. Link to publication
Li, Z. , Yarmush, M. L., and Chan, C., "Insulin concentration during pre-conditioning mediates the regulation of urea synthesis in primary rat hepatocytes during exposure to amino acid supplemented plasma", (2004) Tissue Engineering, 10(11-12): 1737-1746. Link to publication
Li, Z. , and Chan, C., "Integrating gene expression and metabolic profiles", (2004) Journal Biological Chemistry, 279(26): 27124-27137. Link to publication
Kidambi, S. , Chan, C., and Lee, I., “Selective Depositions on Polyelectrolyte Multilayers: Self-Assembled Monolayers of m-dPEG Acid as Molecular Templates”, (2004) JACS, 126(14):4697-4703. Link to publication
Li, Z. , and Chan, C., "Inferring pathways and networks with a Bayesian framework", (2004) FASEB J 18(6): 746-8 (published on-line Feb 6, 2004, doi:10.1096/fj.03-0475fje). Link to publication.
Hwang, D. H., Stephanopoulos, G., and Chan, C., "Inverse modeling using multi-block PLS to determine the environmental conditions that provide optimal cellular function", (2004) Bioinformatics, 20(4):487-99. Link to publication
Chan, C. , Hwang, D. H., Stephanopoulos, G. N., Yarmush, M. L., and Stephanopoulos, G., "Application of Multivariate Analysis to Optimize Function of Cultured Hepatocytes”, (2003) Biotechnology Progress, 19(2): 580-598. Link to publication
Chan, C., Berthiaume, F., Lee, K., and Yarmush, M. L., "Metabolic flux analysis of hepatocyte function in hormone- and amino acid-supplemented plasma", (2003) Metabolic Engineering, 5: 1-15. Link to publication
Chan, C., F., Berthiaume, F., Lee, K., and Yarmush, M. L., "Metabolic Flux Analysis of Cultured Hepatocytes Exposed to Plasma", (2003) Biotechnology and Bioengineering, 81: 33-49. Link to publication
Chan, C., Berthiaume, F., Washuzu, J., Toner, M., and Yarmush, M. L., "Metabolic Pre-Conditioning of Cultured Cells in Physiological Levels of Insulin: Generating Resistance to the Lipid Accumulating Effects of Plasma in Hepatocytes", (2002) Biotechnology and Bioengineering, 78: 753-760. Link to publication
Washizu, J., Berthiaume, F., Chan, C., Tompkins, R. G., Toner, M., and Yarmush, M. L., "Optimization of Rat Hepatocyte Culture in Citrated Human Plasma", (2000) Journal of Surgical Research, 93: 237-246. Link to publication
Washizu, J., Chan, C., Berthiaume, F., Tompkins, R. G., Toner, M., and Yarmush, M. L., "Amino Acid Supplementation Improves Cell-Specific Functions of the Rat Hepatocytes Exposed to Human Plasma", (2000) Tissue Engineering, 6: 497-504. Link to publication
Books, Chapters, Monographs
Berthiaume, F., Chan, C., Yarmush, M. L., “Liver, Bio-artificial”, In Encyclopedia of Biomaterials and Biomedical Engineering, eds. Gary Wnek and Gary Bowlin, Marcel Dekker Inc., New York, NY, 2004, Vol. 1, p.899-909.
Berthiaume, F., Tilles, A. W., Toner, M., Yarmush, M. L., and Chan, C., “Hepatic Tissue Engineering for Adjunct and Temporary Liver Support”, in Tissue Engineering and Artificial Organs, ed. Joseph D. Bronzino, Taylor and Francis, Boca Raton, FL, 2006, Chapter 59, p. 1-19.
Patil, S., Li, Z., and Chan, C., “Approaches to Optimizing Cellular Function of Engineered Tissue: Cellular to Tissue Informatics", Advances in Biochemical Engineering/Biotechnology, eds. K. Lee and D. Kaplan, 2006, volume 102, p. 139-159.
Chan, C., Li, Z., and Srivastava, S., “Integration of Micro-Array and Metabolic Data”, in Mathematical Modeling in Experimental Nutrition, 2007, Chapter 5, p. 82-96.
Srivastava, S., Li, Z., and Chan, C., “Identification of gene-networks associated with cell-death in lipotoxicity”, in Methods in Molecular Biology: Caspase Regulation, ed. Jeffrey Varner, Humana Press Inc., Totowa, NJ, 2007, (accepted).Reviews (Regular and Invited)
Chan, C., Berthiaume, F., Dwarakanath, B., Tilles, A. W., Toner, M., Yarmush, M. L., “Hepatic tissue engineering for adjunct and temporary liver support: Critical technologies”, (2004) Liver Transplantation, 10(11):1331-1342. Link to publication
Walton, SP , Li, Z, and Chan, C, “Biological network analyses: computational genomics and systems approaches”, (2006) Molecular Simulation, 32 (Issue is 3-4, 15 March-April): 203-209.
Conference Proceedings
Jin, R.; Si, L.; Srivastava, S.; Li, Z.; Chan, C. "A Knowledge Driven Regression Model for Gene Expression and Microarray Analysis", EMBC Conference Proceedings, (2006).
Kidambi, S.; Lee, I.; Chan, C. "Salt Tunable m-dPEG Acid Patterns on Polyelectrolyte Multilayers - Templates for Directed Deposition of Macromolecules," Polymer Preprints 47(1), 41-42, (2006).
Other Works
Huebner, M.; Kroos, L.; Chan, C.; Sun, F.; and Cheng, T. "Biological Networks: Design and Dynamics at Different Levels," Department of Statistics and Probability, Technical Report MSU RM639, (2005).