Publications:
Osenkowski, P.*, Li, H.*, Ye, W., Li, D., Aeschbach, L., Fraering, P., Wolfe, M. S., Selkoe, D. J., Li, H. "Cryo-Electron Microscopy Structure of γ-Secretase at 12 A Resolution." 2009. Journal of Molecular Biology, 385 (2): p. 642-52.
Osenkowski, P., Ye, W., Wang, R., Wolfe, M. S., Selkoe, D. J. "Direct Regulation of γ-Secretase by its Lipid Microenvironment." 2008. Journal of Biological Chemistry, 283 (33): p. 22529-40.
Cho, J. A., Osenkowski, P., Zhao, H., Kim, S., Toth, M., Cole, K., Aboukameel, A., Saliganan, A., Schuger, L, Bonfil, R. D., Fridman, R. 2008. "The Inactive 44-kDa Processed Form of MT1-MMP Enhances Proteolytic Activity Via Regulation of Endocytosis of Active MT1-MMP." Journal of Biological Chemistry, 283 (25): p. 17391-17405.
Cacquevel, M., Aeschbach, L., Osenkowski, P., Li, D., Ye, W., Wolfe, M. S., Li, H., Selkoe, D. J., Fraering, P. C. 2008. "Rapid Purification of Active γ-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease." Journal of Neurochemistry. 104(1): p. 210-220.
Bonfil, R. D., Dong, Z., Trindade-Filho, J. C., Sabbota, A., Osenkowski, P., Nabha, S., Yamamoto, H., Chinni, S. R., Zhao, H., Mobashery, S., Vessella, R. L., Fridman, R., Cher, M. L. 2007. "Prostate Cancer-Associated Membrane Type 1-Matrix Metalloproteinase. A Pivotal Role in Bone Response and Intraosseous Tumor Growth." American Journal of Pathology. 170(6): p. 2100-2111.
McClung, H. M., Thomas, S. L., Osenkowski, P., Toth, M., Menon, P., Raz, A., Fridman, R., Rempel, S. A. 2007. "SPARC Upregulates MT1-MMP Expression, MMP-2 Activation, and the Secretion and Cleavage of Galectin-3 in U87MG Glioma Cells." Neuroscience Letters. 419(2): p. 172-177.
Osenkowski, P., Meroueh, S., Pavel, D., Mobashery, S., Fridman, R. 2005. "Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing." Journal of Biological Chemistry, 280 (28): p. 26160-26168.
Toth, M.*, Osenkowski, P.*, Hesek, D., Brown, S., Meroueh, S., Sakr, W., Mobashery, S., Fridman, R. 2005. "Cleavage at the Stem Region Releases an Active Ectodomain of the Membrane Type 1-Matrix Metalloproteinase." Biochemical Journal, 387: p. 497-506.
Osenkowski, P., Toth, M., Fridman, R. 2004. "Processing, Shedding, and Endocytosis of Membrane Type 1- Matrix Metalloproteinase (MT1-MMP)." Journal of Cellular Physiology, 200 (1): p. 2-10.
Zhao, H., Bernardo, M. M., Osenkowski, P., Sohail, A., Pei, D., Nagase, H., Kashiwagi, M., Soloway, P.D., DeClerck, Y.A., Fridman, R. 2004. "Differential Inhibition of MT3-MMP and MT1-MMP by TIMP-2 and TIMP-3 Regulates Pro-MMP-2 Activation." Journal of Biological Chemistry, 279 (10): p. 8592-8601.
Thomas, J. C., Davies, E. C., Malick, F. K., Endreszl, C., Williams, C. R., Abbas, M., Petrella, S., Swisher, K., Perron, M., Edwards, R., Osenkowski, P., Urbanczyk, N., Wiesend, W. N., Murray, K. S. 2004. "Yeast Metallothionein in Transgenic Tobacco Promotes Copper Uptake from Contaminated Soils." Biotechnology Progress, 20 (1): p. 402-409.
Bonfil, R. D., Osenkowski, P., Fridman, R., Cher, M. L. 2004. "Matrix Metalloproteinases and Bone Metastasis" in The Biology of Skeletal Metastases. Keller, E. T., and Chung, L. (eds.), Kluwer Academic Publisher, 118: p. 173-195.
Toth, M., Hernandez-Barrantes, S., Osenkowski, P., Bernardo, M. M., Gervasi, D. C., Shimura, Y., Meroueh, O., Kotra, L. P., Galvez, B. G., Arroyo, A. G., Mobashery, S., Fridman, R. 2002. "Complex Pattern of Membrane Type 1-Matrix Metalloproteinase Shedding. Regulation by Autocatalytic Cell Surface Inactivation of Active Enzyme." Journal of Biological Chemistry, 277 (29): p. 26340-26350.
* Authors contributed equally to this work