Aizhuo Liu
Director, NMR Facility
- B.S. 1984, Jilin University, China
- M.S. 1987, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences
- Ph.D. 1999, Swiss Federal Institute of Technology Zurich (ETH Zurich)
- Assistant/Associate Professor, 1987-1995, CIAC, Chinese Academy of Sciences
- Research Fellow/Research Associate, 1999-2000, Memorial Sloan-Kettering Cancer Center (MSKCC), New York
- Protein NMR Group Leader, 2000-2003, Tularik Inc. South San Francisco
liua@msu.edu
311 Biochemistry Building
Michigan State University
East Lansing, MI 48824-1319
Office: 517-353-4620
FAX: 517-353-9334
NMR Facility
Publication search:
Aizhuo Liu Research Interests continued
- 2. ) New trends of
NMR technique development have been towards the structure determination
of even larger systems, including integral membrane proteins, and the extraction
of new parameters for the structural and dynamic characterizations. One
of my focuses in this area is the direct detection of hydrogen bonds in
a macromolecule and between molecules in a complex. Information on hydrogen
bond networks is very important for the study of enzyme catalysis and molecular
recognition. The introduction of a 900 MHz NMR instrument on MSU campus
through the Michigan Life Science Corridor should provide us with a unique
facility to conduct method development for this purpose.
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3.) Advanced NMR techniques for drug development. NMR is one of most important techniques in drug development and has been used in many stages in the process, from compound screening, structural characterization of both small ligand molecules and large protein targets, to lead generation and modification. One of my efforts is to develop new NMR methods, such as 19F-NMR techniques, for the improvement of the efficiency of compound screening and the enhancement of the information on molecular structure, dynamics, and intermolecular interactions.