Steven J. Triezenberg Professor (on leave)
Current position:
Dean of the Graduate School,
Van Andel Institute, Grand Rapids, MI
- B.S. 1979, Calvin College
- Ph.D. 1984, The University of Michigan
- Helen Hay Whitney Postdoctoral Fellow, 1984-87, Carnegie Institution of Washington
- MSU Teacher-Scholar Award, 1993
- NIH Research Career Development Award, 1994-99
- Distinguished Faculty Award, College of Human Medicine, 1996
Van Andel Institute
333 Bostwick. N.E.
Grand Rapids, MI 49503
Office: 616-234-5704
Lab: 616-234-5109
Publication search:
Steven J. Triezenberg Recent Publications
S.B. Kutluay, J. Doroghazi, M.E. Roemer, and S.J. Triezenberg. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 373:239-247 (2008).
D.D.Shooltz, G.L. Alberts, and S.J. Triezenberg. One-step affinity purification of recombinant TATA binding proteins utilizing a modular protein interaction partner. Protein Expression and Purification 59:297-301 (2008).
Mao Y, Pavangadkar KA, Thomashow MF, Triezenberg SJ. Physical and functional interactions of Arabidopsis ADA2 transcriptional coactivator proteins with the acetyltransferase GCN5 and with the cold-induced transcription factor CBF1. Biochim Biophys Acta. Jan-Feb;1759(1-2):69-79 (2006).
Ottosen S, Herrera FJ, Doroghazi JR, Hull A, Mittal
S, Lane WS, Triezenberg
SJ.
Phosphorylation of the VP16 transcriptional activator protein
during herpes
simplex virus infection and mutational analysis of putative
phosphorylation
sites.
Virology. 345:468-481 (2005).
Wang Z, Triezenberg SJ, Thomashow MF, Stockinger EJ.
Multiple hydrophobic motifs in Arabidopsis CBF1 COOH-terminus
provide
functional redundancy in trans-activation.
Plant Mol Biol. Jul;58(4):543-59 (2005).
J.L. Stebbins and
S.J. Triezenberg. Identification, mutational analysis and coactivator
requirements of two distinct transcriptional activation domains of the
yeast Hap4 protein. Eukaryotic Cell 3: 339-347 (2004).
Y.A. Nedialkov and S.J. Triezenberg. Quantitative assessment of in vitro
interactions implicates TATA-binding protein as a target of the VP16C
transcriptional activation region. Arch. Biochem. Biophys. 425:77-86 (2004).
F. J. Herrera and S.J. Triezenberg. VP16-dependent association of chromatin-modifying
coactivators and underrepresentation of histones at immediate-early promoters
during herpes simplex virus infection. J. Virol.78: 9689-9696 (2004).
Herrera, F.J., Shooltz, D.D., and S. J. Triezenberg. Mechanisms of transcriptional
activation in eukaryotes. Handbook Exp. Pharm. 166:3-31 (2004).
Herrera, F.J., and S.J. Triezenberg. What ubiquitin can do for transcription (commentary). Current Biol 14:R622-R624 (2004). Acrobat File Reprint.
K.E. Vlachonasios, M.F. Thomashow, and S.J. Triezenberg. Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development and gene expression. Plant Cell 15626-638 (2003). Acrobat File Reprint.
D.C. Ducat, F.J. Herrera, F.J., and S.J. Triezenberg. Overcoming obstacles in DNA sequencing of expression plasmids for short interfering RNAs. BioTechniques 341140-1144 (2003).
W. C. Yang, G. V. Devi-Rao, P. Ghazal, E. Wagner, and S. J. Triezenberg. General and specific alterations in programming of global viral gene expression during infection by VP16 activation-deficient mutants of herpes simplex virus type 1. J. Virol. 7612758-12774 (2002). Acrobat File Reprint.
S. Ottosen, FJ Herrera,
and SJ Triezenberg. Transcription. Proteasome parts at gene promoters.
Science. 296:479-481 (2002). Acrobat
File Reprint.
E. J. Stockinger, Y. Mao, M. K. Regier, S. J. Triezenberg and M. F.
Thomashow. Transcriptional adaptor and histone acetyltransferase proteins
in Arabidopsis and their interactions with CBF1, a transcriptional
activator involved in in cold-regulated gene expression. Nucleic Acids
Research. 29:1524-1533 (2001).
Acrobat File Reprint.
R. Tal-Singer, R. Pichyangkura, E. chung, T.M. Lasner, B.P. Randazzo, J.Q. Trojanowski, N.W. Fraser, and S.J. Triezenberg. The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous systems. Virology. 259:20-33 (1999).
Sullivan, S.M., Horn, P.J., Olson, V.A., Koop, A.H., Niu, W., Ebright, R.H., and Triezenberg, S.J. Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus. Nucleic Acids Res. 26:4487-4496 (1998) (corrigendum: vol. 26:23 p. i-ii). Acrobat File Reprint.
Kobayashi, N., Horn, P., Sullivan, S. M., Triezenberg, S. J., Boyer, T. G., and Berk, A. J. (1998). DA-complex assembly activity required for VP16C transcriptional activation. Mol. Cell. Biol. 18:4023-4031 (1998) Acrobat File Reprint.
Shen, F., Triezenberg, S. J., Hensley, P., Porter, D., and Knutson, J. R. (1996). Transcriptional activation domain of the herpes virus protein VP16 becomes conformationally constrained upon interaction with basal transcription factors. J. Biol. Chem. 271:4827-4837.
Triezenberg, S. J. (1995) Structure and function of transcriptional activation domains. Current Opinions in Genetics and Development. 5:190-196.